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KMID : 1149220100180010133
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Korean Journal of Oriental Medical Prescription
2010 Volume.18 No. 1 p.133 ~ p.144
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Effects of Rehmanniae Radix on HPA Axis System and Catecholamienrgic System in FST
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Park Jae-Beom
Lee Tae-Hee
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Abstract
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Objectives:The effects of Rehmanniae Radix(RR) on HPA Axis system and Catecholaminergic system was investigated.
Methods:we performed the Forced Swimming Test(FST). Also the expression of Corticotropin -Releasing Factor(CRF), c-Fos and Tyrosine Hydorxylase(TH) was measured by immunohistochemical method at Paraventricular Nucleus(PVN), Locus Coeruleus(LC) and Ventral Tegmental Area(VTA).
Results:1. The duration of immobility in the Forced Swimming Test was significantly decreased in the Rehmanniae Radix 400 mg/kg groups in comparison with the control group(p<0.05). 2. Comparing to the control group, CRF expression was significantly decreased in the Rehmanniae Radix 400 mg/kg treated group in comparison with the control group(p<0.01). 3. c-Fos expression was significantly decreased at PVN in the Rehmanniae Radix 100 mg/kg treated group in comparison with the control group(p<0.01). 4. TH expression was significantly increased at LC in the Rehmanniae Radix 100 mg/kg and 400 mg/kg treated group in comparison with the control group(p<0.001). 5. TH expression was significantly decreased at VTA in the Rehmanniae Radix 100 mg/kg and 400 mg/kg treated group in comparison with the control group(p<0.001).
Conclusions:According to the results, it can be considered that Rehmanniae Radix has antidepressant effect by showing the reduction of immobility in FST through the decreased expression of CRF, c-Fos in PVN and TH in VTA.
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KEYWORD
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Rehmanniae Radix, FST, CRF, c-Fos, TH, Anti-depression
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